Aloe-emodin mediates the inhibitory effect of LncRNA D63785 on the PI3K/Akt/mTOR pathway in nasopharyngeal carcinoma
AE exerts anti-NPC effects by targeting the lncRNA D63785-PI3K/Akt/mTOR axis, offering a novel therapeutic strategy. These findings bridge AE's pharmacological activity with lncRNA regulatory networks in NPC pathogenesis.
Authors
- Min He (ORCID: https://orcid.org/0000-0003-0361-8984)
- Jianhong Tang (ORCID: https://orcid.org/0000-0002-2349-6155)
- Mengqin Li (ORCID: https://orcid.org/0000-0003-4064-7549)
- Liuping Xie (ORCID: https://orcid.org/0000-0003-2189-5512)
- Jiahua Hu
- Lei Xie (ORCID: https://orcid.org/0000-0002-2303-9173)
- Xin Zeng (ORCID: https://orcid.org/0000-0001-9872-7918)
- Jiayi Huang (ORCID: https://orcid.org/0000-0002-5153-506X)
- Han Su (ORCID: https://orcid.org/0009-0005-4957-6750)
Institutions
- Guilin Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-07-18
- DOI
- https://doi.org/10.3389/fphar.2025.1573408
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.00