Mitochondrial mass and low mitochondrial membrane potential percentage of CD8+ T cell subsets are implicated with therapeutic effect in depressive disorder.
Our results suggest that mitochondrial alterations in CD8+ T-cell subsets may represent immunometabolic adaptations accompanying clinical improvement in depression. MM and MMP<sup>Low</sup> in CD8+ T lymphocytes may serve as preliminary biomarkers for assessing therapeutic response in depression.
Authors
- Zhenni Chen
- Yiran Huang (ORCID: https://orcid.org/0000-0003-1755-9874)
- Xu Yang
- Biqiong Ren (ORCID: https://orcid.org/0000-0002-0562-9348)
Institutions
- Central South University (CN)
- Hunan University of Traditional Chinese Medicine (CN)
- Second People Hospital of Hunan (CN)
- Second Xiangya Hospital of Central South University (CN)
Publication Details
- Journal
- PubMed
- Published
- 2025-01-01
- DOI
- https://doi.org/10.3389/fpsyt.2025.1550958
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00