A DEL-1/αvβ3 integrin axis promotes brown adipocyte progenitor proliferation and cold-induced brown adipose tissue adaptation
Together, the DEL-1/αvβ3 integrin-dependent endothelial-brown adipocyte progenitor cell crosstalk promotes cold-stimulated BAT adaptation. This knowledge could be potentially harnessed therapeutically for promoting BAT expansion towards improving systemic metabolism.
Authors
- Vasileia Ismini Alexaki (ORCID: https://orcid.org/0000-0003-3935-8985)
- Bettina Gercken
- Janine Gebler
- Anke Witt (ORCID: https://orcid.org/0000-0003-4570-715X)
- Kyoung‐Jin Chung (ORCID: https://orcid.org/0000-0001-6584-5352)
- Sylvia Großklaus
- Xiaofei Li (ORCID: https://orcid.org/0000-0002-9585-8661)
- Pallavi Subramanian (ORCID: https://orcid.org/0000-0002-4508-0812)
- Antonios Chatzigeorgiou (ORCID: https://orcid.org/0000-0002-7039-4223)
- Irakli Kopaliani (ORCID: https://orcid.org/0000-0002-2884-3005)
- Khalil Bdeir
- Matthias Blüher (ORCID: https://orcid.org/0000-0003-0208-2065)
- George Hajishengallis (ORCID: https://orcid.org/0000-0001-7392-8852)
- Dong Young Kim (ORCID: https://orcid.org/0000-0001-7594-9083)
- Jong‐Hyung Lim
- Triantafyllos Chavakis
- Ismini Marava
Institutions
- Technische Universität Dresden (DE)
- University of Pennsylvania (US)
Publication Details
- Journal
- Molecular Metabolism
- Published
- 2025-08-05
- DOI
- https://doi.org/10.1016/j.molmet.2025.102229
- Citations
- 1
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- Sächsisches Staatsministerium für Wissenschaft und Kunst
- National Institute of Dental and Craniofacial Research