Deciphering the role of SEMA4A/MAPK signaling in sepsis: insights from Mendelian randomization, transcriptomic, single-cell sequencing analyses, and vitro experiments.
This study proposes SEMA4A, LRPAP1, and NTSR1 as promising therapeutic targets for sepsis. Particularly, it underscores the crucial role of SEMA4A/MAPK in monocytes in the pathogenesis and progression of sepsis, offering valuable insights for potential treatment strategies.
Authors
- Yu-Shen Yang (ORCID: https://orcid.org/0000-0003-0310-3999)
- Yan-Ling Lin
- Zhendong Sun (ORCID: https://orcid.org/0000-0003-2134-6652)
- Ge Wang (ORCID: https://orcid.org/0000-0002-2656-7705)
- Li‐Ying Yu
- Liming Xu (ORCID: https://orcid.org/0000-0002-3577-0959)
- Yifeng Zeng (ORCID: https://orcid.org/0000-0003-2615-5994)
- He-Fan He (ORCID: https://orcid.org/0000-0001-9622-4110)
- Meng-Qin Pei
Institutions
- Fujian Medical University (CN)
- Second Affiliated Hospital of Fujian Medical University (CN)
Publication Details
- Journal
- PubMed
- Published
- 2025-01-01
- DOI
- https://doi.org/10.3389/fcimb.2025.1606509
- Primary Topic
- Inflammation biomarkers and pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00