Inhibition of Unc119b improves insulin sensitivity through potentiation of Rac1 activation in skeletal muscle and brown adipose tissue
Overall, this study identifies Unc119b as a critical regulator of glucose homeostasis, uncovers its role in GLUT4 trafficking, and identifies the mechanism of action of a new class of insulin sensitizers.
Authors
- Julien A. Sebag (ORCID: https://orcid.org/0000-0002-8366-312X)
- Nikolai O. Artemyev (ORCID: https://orcid.org/0000-0002-5266-6854)
- Ayushi Mittal (ORCID: https://orcid.org/0000-0002-0124-6286)
- Paul Buscaglia (ORCID: https://orcid.org/0000-0002-6080-2983)
- Dhiraj Srivastava (ORCID: https://orcid.org/0000-0002-1460-1646)
Institutions
- University of Iowa (US)
- University of Michigan (US)
Publication Details
- Journal
- Molecular Metabolism
- Published
- 2025-08-05
- DOI
- https://doi.org/10.1016/j.molmet.2025.102230
- Citations
- 1
- Primary Topic
- Metabolism, Diabetes, and Cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Institute of Diabetes and Digestive and Kidney Diseases