Aortic stenosis risk and Life’s Crucial 9: the role of proteomics and inflammation
Higher LC9 score was associated with reduced aortic stenosis risk. This inverse relationship was significantly mediated by plasma proteomics and inflammatory biomarkers. These findings underscore the importance of adherence to LC9 guidelines for the prevention of aortic stenosis and provide insights into the biological pathways linking cardiovascular health to aortic stenosis.
Authors
- Xiaoqin Gan (ORCID: https://orcid.org/0009-0002-1906-666X)
- Xianhui Qin (ORCID: https://orcid.org/0000-0001-7812-7982)
- Yiting Wu (ORCID: https://orcid.org/0000-0001-8079-9497)
- Ziliang Ye (ORCID: https://orcid.org/0000-0002-8626-4925)
- Sisi Yang (ORCID: https://orcid.org/0009-0008-2696-9107)
- Yuanyuan Zhang (ORCID: https://orcid.org/0000-0002-5708-9718)
- Yiwei Zhang (ORCID: https://orcid.org/0000-0001-9611-9337)
- Yanjun Zhang (ORCID: https://orcid.org/0000-0003-2176-6657)
- Hao Xiang (ORCID: https://orcid.org/0000-0003-4823-2890)
- Yu Huang
Institutions
- National Clinical Research Center for Digestive Diseases (CN)
- Key Laboratory of Guangdong Province (CN)
- Nanfang Hospital (CN)
- National Clinical Research (US)
- Guangdong Provincial People's Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- European Journal of Preventive Cardiology
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1093/eurjpc/zwaf491
- Citations
- 1
- Primary Topic
- GDF15 and Related Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 1.67