Genetic and sex-specific regulation of mitochondrial function in gonadal and inguinal adipose tissue
Female gWAT shows genetically driven mitochondrial regulation linked to metabolic protection, whereas male iWAT has higher mitochondrial content, OXPHOS expression, and respiration. Elevated lipolytic enzymes in male iWAT suggest greater FFA release, while higher pyruvate import and glyceroneogenesis genes in female gWAT favor FFA recycling. Alpl upregulation in females indicates sex-biased UCP1-independent thermogenesis. These depot- and sex-specific signatures reflect distinct metabolic strategies and highlight the need to consider both in adipose research.
Authors
- Aldons Jake Lusis (ORCID: https://orcid.org/0000-0001-9013-0228)
- Gurugowtham Ulaganathan (ORCID: https://orcid.org/0009-0000-8004-6882)
- Calvin Q. Pan (ORCID: https://orcid.org/0000-0002-3723-6688)
- Dorota Kamińska (ORCID: https://orcid.org/0000-0003-1829-576X)
- Laurent Vergnes (ORCID: https://orcid.org/0000-0002-8804-589X)
- A Ro
Institutions
- University of California, Los Angeles (US)
Publication Details
- Journal
- Molecular Metabolism
- Published
- 2025-08-05
- DOI
- https://doi.org/10.1016/j.molmet.2025.102227
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Heart, Lung, and Blood Institute
- National Institute of Diabetes and Digestive and Kidney Diseases