A heterotrimeric G protein (Gsα) biomarker may predict antidepressant response in subjects with major depressive disorder.
ADT facilitates translocation of Gsα from the lipid raft region, particularly in MDD subjects who respond to ADT. The findings from this small hypothesis-generating study suggest that the Gsα biomarker assay has potential clinical utility to predict ADT response in depressed subjects with low baseline biomarker values. However, these are exploratory findings that must be replicated in larger studies.
Authors
- Mark Hyman Rapaport (ORCID: https://orcid.org/0000-0001-8359-987X)
- Mark M. Rasenick (ORCID: https://orcid.org/0000-0003-2405-4364)
- Alex Leow (ORCID: https://orcid.org/0000-0002-5660-8651)
- Aksu Günay (ORCID: https://orcid.org/0000-0002-2728-1135)
- Steven D. Targum (ORCID: https://orcid.org/0000-0003-1054-5197)
- Olusola Ajilore (ORCID: https://orcid.org/0000-0003-0737-0437)
Institutions
- Illinois College (US)
- Illinois Tool Works (United States) (US)
- University of Utah (US)
- University of Illinois Chicago (US)
- University of Chicago (US)
- Jesse Brown VA Medical Center (US)
Publication Details
- Journal
- PubMed
- Published
- 2025-01-01
- DOI
- https://doi.org/10.3389/fpsyt.2025.1619243
- Primary Topic
- Receptor Mechanisms and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00