Effectiveness of piperacillin/tazobactam loading dose for extended infusion dosing among patients with Gram-negative bacteraemia
Overall, we observed no significant association between LD for extended infusion piperacillin/tazobactam and mortality, and no signal that use of LD was associated with more adverse events. We hypothesize a potential benefit of LD administration for severely ill patients, but larger adequately powered prospective cohorts or randomized trials are needed to examine this.
Authors
- Keith S. Kaye (ORCID: https://orcid.org/0000-0003-2051-1732)
- Marc H. Scheetz (ORCID: https://orcid.org/0000-0002-1091-6130)
- Pinki J. Bhatt (ORCID: https://orcid.org/0000-0002-8177-9903)
- Navaneeth Narayanan (ORCID: https://orcid.org/0000-0001-5071-9193)
- Emily Aboujaoude (ORCID: https://orcid.org/0000-0001-5508-0376)
- Arsheena Yassin (ORCID: https://orcid.org/0000-0002-5039-6301)
- Sana Mohayya (ORCID: https://orcid.org/0000-0001-7304-0124)
- Nathaniel J. Rhodes (ORCID: https://orcid.org/0000-0002-0018-5434)
- Ahmed Abdul Azim (ORCID: https://orcid.org/0000-0001-7940-4320)
- Savan Patel (ORCID: https://orcid.org/0000-0001-7524-6898)
- Judy Dao
Institutions
- Rutgers, The State University of New Jersey (US)
- Midwestern University (US)
- Robert Wood Johnson University Hospital (US)
- Johnson University (US)
- Northwestern Memorial Hospital (US)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2025-08-04
- DOI
- https://doi.org/10.1093/jac/dkaf259
- Primary Topic
- Antibiotics Pharmacokinetics and Efficacy
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases