Fingernail-based metabolomics reveals a stepwise decline in dodecanoic acid associated with Alzheimer’s disease progression
Dodecanoic Acid emerges as a key biomarker reflecting disrupted fatty acid metabolism during AD progression. By enabling long-term metabolic profiling, fingernail metabolomics presents a promising, scalable, and non-invasive strategy for early diagnosis, staging, and monitoring of neurodegenerative diseases.
Authors
- Wuhan Yu (ORCID: https://orcid.org/0000-0002-2889-2704)
- Weihua Yu (ORCID: https://orcid.org/0000-0003-4865-4428)
- Jiani Wu (ORCID: https://orcid.org/0000-0001-7940-4179)
- Zhangjing Deng (ORCID: https://orcid.org/0009-0007-8161-8329)
- Wenbo Zhang (ORCID: https://orcid.org/0000-0001-7071-5931)
- Yang Lü (ORCID: https://orcid.org/0000-0003-1845-7618)
Institutions
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1016/j.jare.2025.07.054
- Citations
- 1
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.81