Tandem CD19/CD22 CAR T-cells as potential therapy for children and young adults with high-risk r/r B-ALL
This work was supported by a grant from the Instituto de Salud Carlos III to APM PI22/01226, two grants from CRIS Cancer Foundation to Beat Cancer as part of the projects "Advanced Cell Therapy Unit Hospital Universitario La Paz" and JM "Proyecto Mateo: CAR T-cell therapy for juvenile myelomonocytic leukaemia" and "Terapia avanzada CAR-T CD19/CD22", Ayuda Nominativa de la Consejería de Investigación, Comunidad de Madrid, Spain. Work in MI lab was funded by a grant from the Spanish Ministry of Science and Innovation (PID2020-114148RB-I00). VGG was granted with Río Hortega (AES 2022 exp. Nº. CM22/00078) and Juan Rodés (AES 2024 exp. Nº. JR24/00003) contracts from the Carlos III Health Institute (ISCIII) through the European Funds of the Recovery, Transformation and Resilience Plan and financed by the European Union NextGenerationEU.
Authors
- Alicia Pernas-Sánchez
- Rimas J. Orentas (ORCID: https://orcid.org/0000-0002-6310-3467)
- Víctor Galán‐Gómez (ORCID: https://orcid.org/0000-0002-2682-9664)
- Berta González‐Martínez
- Elisa Izquierdo (ORCID: https://orcid.org/0000-0002-3054-5832)
- Adela Escudero (ORCID: https://orcid.org/0000-0001-8101-4014)
- Antonio Pérez‐Martínez (ORCID: https://orcid.org/0000-0002-6436-9195)
- Halin Bareke (ORCID: https://orcid.org/0000-0003-4577-3325)
- Pilar Guerra‐García (ORCID: https://orcid.org/0000-0002-7740-0614)
- Isabel Mirones‐Aguilar
- Marta Cobo (ORCID: https://orcid.org/0000-0003-3296-7892)
- Elena Sánchez‐Zapardiel (ORCID: https://orcid.org/0000-0002-1017-0340)
- Peirong Hu
- Sonsoles San Román-Pacheco
- Sara Naharro (ORCID: https://orcid.org/0000-0002-6868-140X)
- Jordi Minguillón (ORCID: https://orcid.org/0000-0003-2124-8294)
- Dina Schneider (ORCID: https://orcid.org/0000-0001-7130-7374)
- Isabel Martínez-Romera
- Manuel Izquierdo (ORCID: https://orcid.org/0000-0002-7701-1002)
- Odelaisy León‐Triana (ORCID: https://orcid.org/0000-0002-7509-7754)
- Carlos Echecopar (ORCID: https://orcid.org/0000-0002-3916-4091)
- Andrés París‐Muñoz (ORCID: https://orcid.org/0000-0002-1926-6429)
- Alfonso Navarro‐Zapata (ORCID: https://orcid.org/0000-0002-5774-8904)
- Susana Vallejo (ORCID: https://orcid.org/0009-0005-4769-5289)
- Alicia Martín-Ayuso
Institutions
- Miltenyi Biotec (Germany) (DE)
- Hospital Universitario La Paz (ES)
- Spanish National Cancer Research Centre (ES)
- Instituto de Investigaciones Biomédicas Sols-Morreale (ES)
- Hospital La Paz Institute for Health Research (ES)
- Lentigen Technology (United States) (US)
- Universidad Autónoma de Madrid (ES)
Publication Details
- Journal
- EBioMedicine
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1016/j.ebiom.2025.105872
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Comunidad de Madrid
- European Commission
- Ministerio de Ciencia e Innovación
- CRIS Cancer Foundation
- Instituto de Salud Carlos III