Fexuprazan mitigates NSAID-induced small intestinal injury by restoring intestinal barrier integrity in mice
Fexuprazan demonstrated protective effects against NSAID-induced small intestinal injury, while esomeprazole did not. Its ability to preserve intestinal barrier integrity, modulate inflammatory responses, and restore gut microbiota composition highlights its therapeutic potential in NSAID-induced enteropathy.
Authors
- Guang‐Yu Yang (ORCID: https://orcid.org/0000-0002-5987-7750)
- Yong Ju Ahn
- Yong‐Sung Kim (ORCID: https://orcid.org/0000-0003-2673-1509)
- Yuju Kim
- Eunok Im (ORCID: https://orcid.org/0000-0002-9949-8819)
- Yunna Lee
- Soyeong Park (ORCID: https://orcid.org/0000-0001-8319-1700)
Institutions
- Korea Gas Corporation (South Korea) (KR)
- Pusan National University (KR)
- Wonkwang University (KR)
Publication Details
- Journal
- Biomedicine & Pharmacotherapy
- Published
- 2025-08-05
- DOI
- https://doi.org/10.1016/j.biopha.2025.118386
- Citations
- 2
- Primary Topic
- Ginger and Zingiberaceae research
- Type
- article
- Field-Weighted Citation Impact
- 3.11