Small-molecule CGRP antagonist atogepant does not affect cortical spreading depression susceptibility in rats
These data suggest that atogepant efficacy in migraine is not mediated via CSD suppression, even when BBB permeability is increased.
Authors
- Cenk Ayata (ORCID: https://orcid.org/0000-0002-3644-6042)
- Xuyan Jin (ORCID: https://orcid.org/0009-0003-1923-4923)
- Qingling Zhai (ORCID: https://orcid.org/0000-0003-1788-1687)
- Andrea M. Harriott (ORCID: https://orcid.org/0000-0003-0417-7586)
- Andreia Morais
- Yuichi Sasaki (ORCID: https://orcid.org/0009-0003-1833-4041)
- Pradeep Banerjee
Institutions
- Harvard University (US)
- AbbVie (United States) (US)
- Massachusetts General Hospital (US)
Publication Details
- Journal
- The Journal of Headache and Pain
- Published
- 2025-08-05
- DOI
- https://doi.org/10.1186/s10194-025-02127-8
- Citations
- 6
- Primary Topic
- Migraine and Headache Studies
- Type
- article
- Field-Weighted Citation Impact
- 8.83
Funders
- AbbVie
- National Institutes of Health