Multilevel Analysis Reveals the Critical Role of Cell Death-Related Molecules and Drugs in Temporomandibular Disorders
Based on multilevel evidence of the blood, tissue and cell, we found that cell death-related genes TIE1, IFI16 and GATM were associated with TMD risk and predict potential target drugs such as fostamatinib. This study further elucidates the critical role of cell death-related molecules and drugs in TMD.
Authors
- Pei Shen (ORCID: https://orcid.org/0000-0003-2839-4649)
- Dahe Zhang (ORCID: https://orcid.org/0000-0003-4248-7569)
- Lingtong Bu
- Jisi Zheng (ORCID: https://orcid.org/0000-0003-0391-8768)
- Xiaoyu Liao (ORCID: https://orcid.org/0000-0001-9851-3848)
- Chi Yang (ORCID: https://orcid.org/0000-0001-7473-7919)
- Yuxin Zhang (ORCID: https://orcid.org/0000-0001-7224-2533)
- Qingyu Xu (ORCID: https://orcid.org/0000-0003-2281-4454)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Shanghai Ninth People's Hospital (CN)
- Suzhou Municipal Hospital (CN)
Publication Details
- Journal
- International Dental Journal
- Published
- 2025-08-05
- DOI
- https://doi.org/10.1016/j.identj.2025.100934
- Citations
- 1
- Primary Topic
- Ubiquitin and proteasome pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.81