Wnt/ERK/CDK4/6 activation in the partial EMT state coordinates mammary cancer stemness with self-renewal and inhibition of differentiation
These findings unravelled a mechanism whereby the hybrid EMT state regulates stemness, self-renewal and differentiation via transient Wnt/ERK/CDK4/6 activation, which can be leveraged for cancer stem cell therapy.
Authors
- Outhiriaradjou Benard
- Rachel B. Hazan (ORCID: https://orcid.org/0000-0002-1441-4584)
- Xusheng Zhang (ORCID: https://orcid.org/0000-0002-9335-5577)
- Kalaiselvi Sivalingam
- Viney Kumar (ORCID: https://orcid.org/0000-0003-3677-3489)
- Jinghang Zhang (ORCID: https://orcid.org/0000-0003-1436-6460)
- Larry Norton (ORCID: https://orcid.org/0000-0003-3701-9250)
- Lindsay M. LaFave (ORCID: https://orcid.org/0000-0002-5203-4961)
- Zuen Ren (ORCID: https://orcid.org/0000-0001-5951-1292)
- Elena de Simone Benito (ORCID: https://orcid.org/0009-0003-3119-4370)
- Huizhi Liang (ORCID: https://orcid.org/0000-0003-4408-4528)
- Anthony Griffen
- Kimita Suyama
Institutions
- Albert Einstein College of Medicine (US)
- Memorial Sloan Kettering Cancer Center (US)
- Harvard University (US)
- Universidad Francisco de Vitoria (ES)
- Massachusetts General Hospital (US)
- Center for Cancer Research (US)
Publication Details
- Journal
- British Journal of Cancer
- Published
- 2025-06-24
- DOI
- https://doi.org/10.1038/s41416-025-03074-6
- Citations
- 1
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 1.05
Funders
- Breast Cancer Research Foundation
- Albert Einstein Cancer Center
- Cure Brain Cancer Foundation
- National Institutes of Health
- National Cancer Institute