Evaluation of the irritation and sensitization potential of medical-grade Norway spruce ( <i>Picea abies</i> ) resin salve: single-blind modified draize human repeat insult patch test in healthy volunteers

The HRIPT findings demonstrate that medical-grade <i>Picea abies</i> resin salve has a low irritation and sensitisation potential under the conditions tested. Although rare allergic contact dermatitis cases have been reported, the data of this study suggests that the overall risk in the general population is low. These findings are also supported by clinical studies and extensive post-market surveillance of Abilar^® in wound care for both acute and chronic wounds.