Use of p53 immunohistochemistry can improve diagnostic agreement for differentiated vulvar intraepithelial neoplasia ( <scp>dVIN</scp> ): an international reproducibility study
Our findings indicate that p53-IHC is a robust ancillary tool that can be reproducibly interpreted by pathologists with varying experience levels and supports the routine use of p53-IHC in cases where dVIN is considered in the differential diagnosis.
Authors
- Jennifer M. Roberts (ORCID: https://orcid.org/0000-0001-7229-8617)
- Anne‐Sophie Van Rompuy (ORCID: https://orcid.org/0000-0002-0138-4486)
- James Scurry (ORCID: https://orcid.org/0000-0001-5074-1200)
- Shatavisha Dasgupta (ORCID: https://orcid.org/0000-0003-1804-5015)
- Demaretta Rush
- Patricia Guzmán (ORCID: https://orcid.org/0000-0002-3376-802X)
- Koen Van de Vijver (ORCID: https://orcid.org/0000-0002-2026-9790)
- Patricia C. Ewing‐Graham (ORCID: https://orcid.org/0000-0002-1779-1115)
- Lex A. C. F. Makkus
- Mieke Van Bockstal (ORCID: https://orcid.org/0000-0003-4498-928X)
- Folkert J. van Kemenade (ORCID: https://orcid.org/0000-0002-4225-4354)
- Maaike C.G. Bleeker (ORCID: https://orcid.org/0000-0001-9610-8064)
- Loes Kooreman (ORCID: https://orcid.org/0000-0001-8226-8665)
- Debra S. Heller (ORCID: https://orcid.org/0000-0002-8378-4642)
- Kathleen Lambein
- Katy R. Veprauskas
- Joost Bart (ORCID: https://orcid.org/0000-0002-0985-071X)
- Senada Koljenović (ORCID: https://orcid.org/0000-0002-5185-3455)
- Rupali Arora (ORCID: https://orcid.org/0000-0001-9087-4876)
- María del Carmen Luís Álvarez
- Radhika Srinivasan (ORCID: https://orcid.org/0000-0002-1771-091X)
- Suzanne Wilhelmus (ORCID: https://orcid.org/0000-0002-7794-5315)
- Maria Angelica Selim
- F. Plantier
- Christine Bergeron
- Russell Ball
- Mahfooz Basha Mohamed (ORCID: https://orcid.org/0009-0001-1701-3778)
- Noel Jean‐Christophe
Institutions
- Rutgers, The State University of New Jersey (US)
- Broad Institute (US)
- Cliniques Universitaires Saint-Luc (BE)
- University Medical Center Groningen (NL)
- University College London Hospitals NHS Foundation Trust (GB)
- University of Arizona (US)
- University of Antwerp (BE)
- University of North Carolina at Greensboro (US)
- Duke University (US)
- University of New Hampshire at Manchester (US)
- John Hunter Hospital (AU)
- Ghent University Hospital (BE)
- Erasmus MC (NL)
- Erasmus Hospital (BE)
- Maastricht University (NL)
- Hôpital Cochin (FR)
- Douglass Hanly Moir Pathology (AU)
- Cancer Research Institute Ghent (BE)
- Duke Medical Center (US)
- PathoFinder (Netherlands) (NL)
- Computer Emergency Response Team (FR)
- Dordrecht Hospital (ZA)
- Amsterdam University Medical Centers (NL)
- AZ Sint-Lucas (BE)
- University College London (GB)
- Post Graduate Institute of Medical Education and Research (IN)
- University of Newcastle Australia (AU)
- Vrije Universiteit Amsterdam (NL)
- KU Leuven (BE)
Publication Details
- Journal
- Histopathology
- Published
- 2025-08-05
- DOI
- https://doi.org/10.1111/his.15524
- Primary Topic
- Cervical Cancer and HPV Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00