Explore the potential mechanism of Huachansu injection against osteosarcoma via metabolomics, network pharmacology and bioinformatics
HCSI could inhibit osteosarcoma progression by regulating lipid metabolism through BCYRN1-miR-27a-3p-HMGCR axis, indicating that HCSI may provide insights for developing herbal medicine injection-based therapies for osteosarcoma.
Authors
- Yonglong Han (ORCID: https://orcid.org/0000-0001-8655-5805)
- Lingyan Xu (ORCID: https://orcid.org/0000-0002-8666-5219)
- Danfeng Xiang (ORCID: https://orcid.org/0000-0002-1089-1519)
- Xiangqi Zhang (ORCID: https://orcid.org/0000-0003-1491-3436)
- Shuai Zhao
- Yang Jiao (ORCID: https://orcid.org/0000-0001-8927-9367)
- Haoyang Liang (ORCID: https://orcid.org/0000-0002-8464-9610)
- Junjun Chen (ORCID: https://orcid.org/0000-0001-7968-7471)
- Jingxian Zhang (ORCID: https://orcid.org/0009-0000-4904-773X)
- Jingjing Meng (ORCID: https://orcid.org/0000-0001-9252-6525)
Institutions
- Shanghai Jiao Tong University (CN)
- Shanghai Sixth People's Hospital (CN)
- Shanghai Ocean University (CN)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2025-08-05
- DOI
- https://doi.org/10.1186/s13020-025-01179-x
- Primary Topic
- Pharmacological Effects of Natural Compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Innovative Research Group Project of the National Natural Science Foundation of China
- Health and Family Planning Committee of Pudong New Area