Tumor Cells‐Derived <scp>FGF</scp> ‐2 Promotes Lymphangiogenesis as a Prognostic Marker in <scp>OSCC</scp>
Our data suggest that FGF-2 is a significant prognostic factor that induces lymphangiogenesis and affects intratumoral CD8+ T cells, contributing to the formation of a "cold" tumor microenvironment in OSCC. FGF-2/FGFR1 could serve as an effective target for improving the prognosis of OSCC.
Authors
- Qiaoshi Xu
- Guo-Ming Chen (ORCID: https://orcid.org/0000-0002-2629-5420)
- Zhengxue Han (ORCID: https://orcid.org/0000-0002-9508-1098)
- Lin Zhu (ORCID: https://orcid.org/0000-0001-9872-459X)
- Aoming Cheng
- Jia Kang (ORCID: https://orcid.org/0009-0004-0188-1724)
Institutions
- Capital Medical University (CN)
- Beijing Obstetrics and Gynecology Hospital (CN)
Publication Details
- Journal
- Journal of Oral Pathology and Medicine
- Published
- 2025-08-05
- DOI
- https://doi.org/10.1111/jop.70019
- Citations
- 1
- Primary Topic
- Lymphatic System and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.05
Funders
- National Natural Science Foundation of China
- Beijing Municipal Natural Science Foundation