Targeting MET and KRAS G12C co-occurring mutation in metastatic adenoid cystic carcinoma of the trachea: a case report
MET p.D1010Y and KRAS p.G12C comutation is extremely rare and could happen concurrently in the same group of cells of metastatic tracheal adenoid cystic carcinoma; crizotinib combined with trametinib is effective, and the toxicities are manageable.
Authors
- Youxin Ji (ORCID: https://orcid.org/0000-0003-2303-8784)
- Keke Nie (ORCID: https://orcid.org/0000-0003-2895-4730)
- Yan Xu (ORCID: https://orcid.org/0000-0002-2381-4467)
- Tonghui Wang (ORCID: https://orcid.org/0000-0003-3002-5092)
- Ling Zhang (ORCID: https://orcid.org/0009-0005-5935-5097)
Institutions
- Qingdao University (CN)
- Shuozhou Central Hospital (CN)
- Affiliated Hospital of Qingdao University (CN)
- Qingdao Municipal Hospital (CN)
Publication Details
- Journal
- Journal of Medical Case Reports
- Published
- 2025-08-05
- DOI
- https://doi.org/10.1186/s13256-025-05246-7
- Primary Topic
- Oral and Maxillofacial Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00