Hepatoprotective Effects of Gac (Momordica cochinchinensis) Aril Extract in Acetaminophen-Induced Liver Injury: Modulation of Oxidative Stress, Inflammation, and Glucose Metabolism
MC exhibits hepatoprotective effects against APAP-induced liver injury through multifaceted modulation of toxic metabolism (CYP2E1), cell death and ER stress (JNK, Ddit3, Bax, Casp3, and Bcl-2), antioxidant response (Nrf2 pathway), inflammation (NF-κB pathway and IL-10), tissue repair (VEGF), and glucose metabolism (AdipoR1, GLUT-2, and PEPCK).
Authors
- Sarawut Sangkham (ORCID: https://orcid.org/0000-0002-0507-0177)
- Narongsuk Munkong (ORCID: https://orcid.org/0000-0002-0097-6746)
- Ratsada Praphasawat (ORCID: https://orcid.org/0000-0001-8082-1623)
- Nuntiya Somparn (ORCID: https://orcid.org/0000-0002-9134-0099)
- Nattanida Jantarach (ORCID: https://orcid.org/0000-0003-1273-7934)
- Kanathip Singsai (ORCID: https://orcid.org/0000-0002-8558-9787)
- Piyanuch Lonan (ORCID: https://orcid.org/0000-0001-6641-4642)
- Bhornprom Yoysungnoen (ORCID: https://orcid.org/0000-0001-7023-3561)
- Varitha Ariyabukalakorn (ORCID: https://orcid.org/0009-0008-6893-6100)
- Prathakphong Riyamongkhol
Institutions
- Thammasat University (TH)
- Khon Kaen University (TH)
- University of Phayao (TH)
Publication Details
- Journal
- Journal of Experimental Pharmacology
- Published
- 2025-08-01
- DOI
- https://doi.org/10.2147/jep.s517411
- Citations
- 2
- Primary Topic
- Drug-Induced Hepatotoxicity and Protection
- Type
- article
- Field-Weighted Citation Impact
- 3.11