Fixation method influences FLASH skin sparing in an in vivo leg model
CONV-treated tape-fixated mice were more radioresistant than the glue-fixated mice, consistent with the expected response to mild hypoxia. FLASH-treated mice were unaffected. These findings demonstrate the impact of fixation and, in turn, oxygen level on the differential CONV versus FLASH skin response. The results highlight the importance of minimal systemic influence on animals during FLASH studies.
Authors
- Jacob Johansen (ORCID: https://orcid.org/0000-0001-8475-0447)
- Line Kristensen (ORCID: https://orcid.org/0000-0003-0924-475X)
- Niels Bassler (ORCID: https://orcid.org/0000-0002-4160-1078)
- Brita Singers Sørensen (ORCID: https://orcid.org/0000-0002-3955-4735)
- P.R. Poulsen (ORCID: https://orcid.org/0000-0001-9940-7609)
- Anna Mette Hansen (ORCID: https://orcid.org/0000-0003-1162-8592)
- Cathrine Overgaard (ORCID: https://orcid.org/0000-0002-8546-2735)
Institutions
- Aarhus University Hospital (DK)
Publication Details
- Journal
- Acta Oncologica
- Published
- 2025-08-05
- DOI
- https://doi.org/10.2340/1651-226x.2025.43972
- Citations
- 6
- Primary Topic
- Tissue Engineering and Regenerative Medicine
- Type
- article
- Field-Weighted Citation Impact
- 12.04
Funders
- Novo Nordisk
- Novo Nordisk Fonden
- Siemens Healthineers