A Network Pharmacology-Based Investigation into the Mechanism of Quercetin Combined with Rosuvastatin in Delaying Diabetic Nephropathy via Inhibiting NRK-52E Cell Ferroptosis
This study highlights the potential of combining QCT and RSV for DN management. Network pharmacology confirmed associations between QCT/RSV targets and NRK-52E cell ferroptosis. In vitro experiments validated superior protective effects of co-treatment over individual treatments, warranting further in vivo investigation.
Authors
- Jingxue Ma (ORCID: https://orcid.org/0000-0002-7898-7912)
- Meishe Gan
- Zhiyuan Lin (ORCID: https://orcid.org/0000-0003-3728-3510)
- Ning Li (ORCID: https://orcid.org/0000-0003-3175-8343)
- B T Wu
Institutions
- Guangxi Medical University (CN)
- Affiliated Hospital of Youjiang Medical University for Nationalities (CN)
- Baise University (CN)
Publication Details
- Journal
- Diabetes Metabolic Syndrome and Obesity
- Published
- 2025-08-01
- DOI
- https://doi.org/10.2147/dmso.s524983
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Guangxi Province