Production of 211At and automated radiosynthesis of [211At]MABG via electrophilic astatodesilylation
In this study, we established a reliable and scalable production methodology for [<sup>211</sup>At]MABG, consistently achieving high radiochemical yield and purity across a wide range of radioactivity levels through optimization of the automated radiosynthesis process and the use of radiolytic stabilizers. This approach provides a solid technical foundation for the clinical application of [<sup>211</sup>At]MABG in targeted alpha therapy.
Authors
- Kazuhiro Takahashi (ORCID: https://orcid.org/0000-0002-8983-1884)
- Kohshin Washiyama (ORCID: https://orcid.org/0000-0002-9908-8756)
- Hiroshi Tanaka (ORCID: https://orcid.org/0000-0002-8779-1460)
- Naoko Hasegawa (ORCID: https://orcid.org/0000-0003-1097-8232)
- Yuto Kondo (ORCID: https://orcid.org/0000-0003-3529-9703)
- Tatsuya Higashi (ORCID: https://orcid.org/0000-0002-8338-4737)
- S. SASAKI
- Noriko S. Ishioka
- Naoyuki Ukon (ORCID: https://orcid.org/0000-0002-6715-582X)
- Taiki Joho
- Ken‐ichi Nishijima (ORCID: https://orcid.org/0000-0002-7189-465X)
- Katsura Mochizuki
Institutions
- Tokyo Institute of Technology (JP)
- Fukushima Medical University (JP)
- Nikon (Japan) (JP)
- National Institutes for Quantum Science and Technology (JP)
- Juntendo University Urayasu Hospital (JP)
Publication Details
- Journal
- EJNMMI Radiopharmacy and Chemistry
- Published
- 2025-08-05
- DOI
- https://doi.org/10.1186/s41181-025-00376-1
- Citations
- 2
- Primary Topic
- Medical Imaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 2.72
Funders
- Japan Society for the Promotion of Science