CAR Macrophages Engineered In Vivo for Attenuating Myocardial Ischemia-Reperfusion Injury
Our study demonstrates that FAP CAR macrophages generated in vivo by LNP-FAP CAR treatment effectively mitigate cardiac fibrosis and improve heart function after I/R injury, with lasting benefits and no observed toxicity. This safe and adaptable platform offers a promising treatment strategy for myocardial I/R injury and holds potential for treating other fibrotic heart diseases.
Authors
- Yanan Meng (ORCID: https://orcid.org/0000-0003-4569-3691)
- Jiahe Zhang
- Jianghua Shen (ORCID: https://orcid.org/0000-0002-4606-542X)
- Yuan Hai-long (ORCID: https://orcid.org/0009-0006-3930-525X)
- Yanan Zhou (ORCID: https://orcid.org/0000-0002-4880-6439)
- Moshi Song (ORCID: https://orcid.org/0000-0001-9929-8975)
- Chuting He
- Xintong You (ORCID: https://orcid.org/0000-0003-4932-4068)
- Zeyu Gao (ORCID: https://orcid.org/0000-0002-3594-8366)
- Pengfei Xu (ORCID: https://orcid.org/0000-0002-0389-1182)
- Heng Du (ORCID: https://orcid.org/0009-0006-1950-9650)
- Chaofan Yang
- Yuhan Wang (ORCID: https://orcid.org/0009-0006-8868-5316)
- Siqi Liu
- Hao Zhang (ORCID: https://orcid.org/0000-0001-9474-3195)
- Yujing Li (ORCID: https://orcid.org/0000-0002-4363-2484)
- Xu Liu (ORCID: https://orcid.org/0000-0002-5107-1074)
- Tuo Wei (ORCID: https://orcid.org/0000-0002-2823-9721)
- Jian Zang (ORCID: https://orcid.org/0009-0001-1251-977X)
- Yi Xiao
Institutions
- World Wide Web Consortium (US)
Publication Details
- Journal
- Circulation Research
- Published
- 2025-08-05
- DOI
- https://doi.org/10.1161/circresaha.125.326716
- Citations
- 21
- Primary Topic
- Mechanical Circulatory Support Devices
- Type
- article
- Field-Weighted Citation Impact
- 14.16