Dicer Neosynthesis Regulates Platelet Reactivity: A Mechanism Altered in Type 2 Diabetes
The Dicer-triggered decrease in P2Y<sub>12</sub> after thrombin stimulation may represent a self-regulatory mechanism of platelet activation to prevent undesired thrombus formation. The derangement of this self-regulatory mechanism in T2DM may contribute to the platelet hyperreactivity and enhanced thrombotic complications of patients with T2DM. Our results show that the complex regulatory role of microRNA neoformation during platelet activation, when deranged, may contribute to cardiovascular disease.
Authors
- Paolo Gresele (ORCID: https://orcid.org/0000-0001-5365-8445)
- Michelantonio De Fano (ORCID: https://orcid.org/0000-0002-2657-5991)
- Elisa Piselli
- Giorgia Manni (ORCID: https://orcid.org/0000-0002-5697-2648)
- Jesse W. Rowley (ORCID: https://orcid.org/0000-0003-4444-1724)
- Carmine G. Fanelli (ORCID: https://orcid.org/0000-0003-4063-158X)
- Giulia Ciarrocca Taranta (ORCID: https://orcid.org/0000-0003-4339-652X)
- Loredana Bury (ORCID: https://orcid.org/0000-0003-0333-0948)
- Stefania Momi
- Andrew S. Weyrich (ORCID: https://orcid.org/0000-0003-1654-6529)
- Giuseppe Guglielmini (ORCID: https://orcid.org/0000-0002-8678-8518)
Institutions
- University of Utah (US)
- University of Perugia (IT)
Publication Details
- Journal
- Circulation Research
- Published
- 2025-08-05
- DOI
- https://doi.org/10.1161/circresaha.124.325357
- Citations
- 1
- Primary Topic
- Adipokines, Inflammation, and Metabolic Diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- Fondazione Cariplo
- Ministero dell’Istruzione, dell’Università e della Ricerca
- Fondazione Umberto Veronesi
- Università degli Studi di Perugia
- Università degli Studi di Urbino Carlo Bo
- School of Medicine