Hypertriglyceridemia as a Key Contributor to Abdominal Aortic Aneurysm Development and Rupture: Insights From Genetic and Experimental Models
These findings identify hypertriglyceridemia as a key contributor to AAA pathogenesis and suggest that targeting TG-rich lipoproteins may be a promising therapeutic strategy for AAA.
Authors
- Anna Schwendeman (ORCID: https://orcid.org/0000-0002-8023-8080)
- Y. Eugene Chen (ORCID: https://orcid.org/0000-0003-2357-7825)
- Guizhen Zhao (ORCID: https://orcid.org/0000-0002-2648-8986)
- Ida Surakka (ORCID: https://orcid.org/0000-0002-6669-5541)
- Hong Lü (ORCID: https://orcid.org/0000-0002-0577-2558)
- Yaozhong Liu (ORCID: https://orcid.org/0000-0003-1994-2025)
- Xiaokang Wu (ORCID: https://orcid.org/0000-0003-1020-6232)
- Ryan E. Temel (ORCID: https://orcid.org/0000-0002-9599-804X)
- Yongjie Deng
- Hong Yu Liu (ORCID: https://orcid.org/0000-0003-1754-0145)
- Huilun Wang (ORCID: https://orcid.org/0000-0002-0583-1386)
- Haocheng Lu (ORCID: https://orcid.org/0000-0002-5740-8010)
- Alan Daugherty (ORCID: https://orcid.org/0000-0003-2093-3775)
- Lin Chang (ORCID: https://orcid.org/0000-0002-5621-8426)
- Lei Cai (ORCID: https://orcid.org/0000-0001-8535-530X)
- Yanhong Guo (ORCID: https://orcid.org/0000-0002-3334-9159)
- Minzhi Yu (ORCID: https://orcid.org/0000-0002-3141-7285)
- Yang Zhao (ORCID: https://orcid.org/0000-0002-1428-5145)
- Jifeng Zhang (ORCID: https://orcid.org/0000-0001-5161-4705)
- Chao Xue (ORCID: https://orcid.org/0000-0002-6528-3975)
- Ying Zhao (ORCID: https://orcid.org/0000-0002-7022-9391)
- Yalun Cheng
Institutions
- University of Kentucky (US)
- University of Michigan (US)
- Southern University of Science and Technology (CN)
- World Wide Web Consortium (US)
- Rochester General Hospital (US)
- Michigan Center for Translational Pathology (US)
- University of Houston (US)
- University of Virginia (US)
Publication Details
- Journal
- Circulation
- Published
- 2025-08-05
- DOI
- https://doi.org/10.1161/circulationaha.125.074737
- Citations
- 9
- Primary Topic
- Aortic aneurysm repair treatments
- Type
- article
- Field-Weighted Citation Impact
- 13.67