Single-Cell Multi-Omics Identifies Specialized Cytotoxic and Migratory CD8 <sup>+</sup> Effector T Cells in Acute Myocarditis
Our study provides a comprehensive immune landscape for understanding the pathogenesis of AM, especially in FM, highlighting clonal CD57<sup>+</sup>CD8<sup>+</sup> effector T cells with high cytotoxicity and migration potential, along with their upstream inflammatory signals, as potential therapeutic targets for mitigating immune-related cardiac damage in AM management, especially in FM.
Authors
- Shuang Yang (ORCID: https://orcid.org/0000-0001-7958-0594)
- Haibo Jia (ORCID: https://orcid.org/0000-0001-9968-4024)
- Dong-Ni Wang (ORCID: https://orcid.org/0000-0003-4570-0281)
- Zhonghua Tong
- Yong Ji (ORCID: https://orcid.org/0000-0003-2650-5747)
- Bo Yu (ORCID: https://orcid.org/0000-0002-5955-6332)
- Lishuang Qi (ORCID: https://orcid.org/0000-0002-2991-6544)
- Zi‐Qi Zheng (ORCID: https://orcid.org/0009-0003-1495-5027)
- P Wang (ORCID: https://orcid.org/0000-0003-2318-903X)
- Xiangyu Yan (ORCID: https://orcid.org/0009-0007-4602-105X)
- Jing Cui
- Yunling Li (ORCID: https://orcid.org/0000-0002-9568-2053)
- Jing Sui （Beijing Normal University）， my correct affiliation is beijing normal university, not Qingdao University of Science and Technology, please correct the current affiliation. Thank you (ORCID: https://orcid.org/0000-0001-6837-5966)
- Di Su (ORCID: https://orcid.org/0000-0003-3612-2379)
- Qiannan Yang
- Fang Liu (ORCID: https://orcid.org/0000-0002-8354-3697)
- Jiaxuan Li (ORCID: https://orcid.org/0000-0002-3999-4183)
- Yanping Li (ORCID: https://orcid.org/0000-0002-5771-0252)
- Xiaoqi Wang (ORCID: https://orcid.org/0000-0002-2700-1017)
- Tao Chen (ORCID: https://orcid.org/0000-0003-3758-4743)
- Jiaxing Deng
- Yingjin Kong (ORCID: https://orcid.org/0009-0005-4767-2474)
- Zhaoying Li (ORCID: https://orcid.org/0009-0005-7860-5581)
- Maomao Zhang (ORCID: https://orcid.org/0000-0001-5649-7931)
- Naixin Wang (ORCID: https://orcid.org/0000-0003-3344-0021)
- Yujia Chen (ORCID: https://orcid.org/0009-0000-7779-5559)
- Yafei Zhang (ORCID: https://orcid.org/0000-0002-2240-3236)
- Zexi Jin
- Weijun Song
- Shuang Liu (ORCID: https://orcid.org/0000-0002-8339-1574)
Institutions
- Heilongjiang University of Science and Technology (CN)
- Harbin Medical University (CN)
- World Wide Web Consortium (US)
- Second Affiliated Hospital of Harbin Medical University (CN)
- Education Department of Heilongjiang Province (CN)
- Heilongjiang Institute of Technology (CN)
- Heilongjiang University (CN)
- ZTE (United States) (US)
Publication Details
- Journal
- Circulation
- Published
- 2025-08-05
- DOI
- https://doi.org/10.1161/circulationaha.125.073836
- Citations
- 6
- Primary Topic
- Viral Infections and Immunology Research
- Type
- article
- Field-Weighted Citation Impact
- 8.33
Funders
- Harbin Medical University
- Key Research and Development Program of Heilongjiang
- National Natural Science Foundation of China