Myeloid-Specific STING-YBX1 Interaction Alleviates Coagulation in Deep Vein Thrombosis
These findings highlight the critical role of myeloid-specific STING-YBX1 signaling in driving inflammation during DVT progression. The potential therapeutic use of STING inhibitors, particularly the synthetic peptide C-ST16, presents a promising approach for DVT management, offering novel insights into targeted anti-inflammatory therapies for thrombotic disorders.
Authors
- Zhiye Guo (ORCID: https://orcid.org/0009-0007-0753-1049)
- Feng Ran
- Chunlei Xing (ORCID: https://orcid.org/0000-0003-0212-7286)
- Dandan Xu (ORCID: https://orcid.org/0000-0002-8576-6050)
- Li Su (ORCID: https://orcid.org/0000-0002-4556-6863)
- Zhiguang Shi
- Shan Lu (ORCID: https://orcid.org/0000-0002-7795-6356)
- Xiaolong Du (ORCID: https://orcid.org/0000-0001-9487-2894)
Institutions
- Zunyi Medical University (CN)
- Shanghai Jiao Tong University (CN)
- Nanjing Drum Tower Hospital (CN)
- Jiangsu Provincial Hospital of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Circulation Research
- Published
- 2025-08-05
- DOI
- https://doi.org/10.1161/circresaha.125.326540
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00