Lanosdracaenin A and (±)-Neodracaflavonoids A, Triterpenoid and Flavonoids with Anti-Inflammatory Activities from <i>Dracaena cochinchinensis</i>
Lanosdracaenin A (<b>1</b>), an unprecedented triterpenoid, featuring a cleaved C ring and a lactonized D ring, and (±)-neodracaflavonoids A [(±)-<b>2</b>], a pair of rearranged flavonoids, were isolated from the resinous wood of <i>Dracaena cochinchinensi</i>. The absolute configurations of these compounds were determined by NMR spectroscopy, ECD calculations, and X-ray crystallography. All compounds exhibited significant anti-inflammatory effects in zebrafish model and LPS-stimulated RAW264.7 cells and suppressed the expression of the inflammation related genes <i>IL-1β</i> and <i>IL-6</i>.
Authors
- Yinglin Zheng (ORCID: https://orcid.org/0000-0003-4671-6111)
- Ren‐Wang Jiang (ORCID: https://orcid.org/0000-0002-0730-9866)
- Xiaoyun Lu (ORCID: https://orcid.org/0000-0001-7931-6873)
- Hai‐Yan Tian (ORCID: https://orcid.org/0000-0002-2421-8712)
- Xue Zhang (ORCID: https://orcid.org/0000-0003-3747-160X)
- Jinchang Liu (ORCID: https://orcid.org/0009-0003-3307-0451)
- Junping Pei (ORCID: https://orcid.org/0009-0002-9685-0124)
- Wei Li (ORCID: https://orcid.org/0000-0001-6843-1980)
- Jing‐Xin Liu
- Weihuan Huang (ORCID: https://orcid.org/0000-0003-4920-5448)
- Yanfu Wang
Institutions
- Ministry of Education (NZ)
- Jinan University (CN)
- Ministry of Education (TH)
- Shenzhen Technology University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-08-05
- DOI
- https://doi.org/10.1021/acs.orglett.5c02756
- Citations
- 2
- Primary Topic
- Phytochemical Studies and Bioactivities
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province
- Guangzhou Municipal Science and Technology Project
- Science and Technology Planning Project of Guangdong Province