Persistent Inflammation, Maladaptive Remodeling, and Fibrosis in the Kidney Following Long COVID-like MHV-1 Mouse Model
MHV-1-induced long COVID is associated with persistent transcriptional reprogramming in the kidney, indicative of chronic inflammation, cytoskeletal dysregulation, and fibrogenesis. SPK demonstrates robust therapeutic potential by normalizing these molecular signatures and preventing long-term renal damage. These findings underscore the relevance of the MHV-1 model and support further investigation of SPK as a candidate therapy for COVID-19-associated renal sequelae.
Authors
- Michael J. Paidas (ORCID: https://orcid.org/0000-0001-5561-7196)
- Rajalakshmi Ramamoorthy (ORCID: https://orcid.org/0000-0001-6992-0612)
- Klaus Schmitz‐Abe (ORCID: https://orcid.org/0000-0002-7242-8861)
- Pankaj B. Agrawal (ORCID: https://orcid.org/0000-0003-3255-0456)
- Eric J. West (ORCID: https://orcid.org/0009-0001-2421-2134)
- Arumugam R. Jayakumar (ORCID: https://orcid.org/0009-0009-2115-7860)
- M. Ramesh
- Anna Rosa Speciale
- Hussain Hussain
Institutions
- University of Miami (US)
- Jackson Health System (US)
- University of Miami Hospital (US)
- University of Florence (IT)
Publication Details
- Journal
- Diseases
- Published
- 2025-08-05
- DOI
- https://doi.org/10.3390/diseases13080246
- Citations
- 1
- Primary Topic
- Diabetes and associated disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.82