Performance of computed tomography and magnetic resonance morphometry in evaluating brain atrophy in Down syndrome
Voxel-based morphometry shows that computed tomography (CT) and magnetic resonance imaging (MRI) yield similar brain atrophy patterns in DS. Strong agreement (kappa index 0.71) was found between CT and MRI assessments. CT-identified right temporal lobe volume loss linked to cognitive decline in DS. CT offers a practical, accessible alternative to MRI for brain imaging in DS. Artificial intelligence-based CT analysis enhances neuroimaging for DS with reduced motion issues.
Authors
- Parashkev Nachev (ORCID: https://orcid.org/0000-0002-2718-4423)
- Bryan A. Strange (ORCID: https://orcid.org/0000-0001-6476-4091)
- John Ashburner (ORCID: https://orcid.org/0000-0001-7605-2518)
- Mikael Brudfors (ORCID: https://orcid.org/0000-0002-2884-2336)
- Diego Real de Asúa (ORCID: https://orcid.org/0000-0002-1445-5597)
- Fernando Moldenhauer (ORCID: https://orcid.org/0000-0002-6259-8226)
- Beatriz Sánchez Moreno (ORCID: https://orcid.org/0000-0002-5182-5745)
- Mateus Rozalem‐Aranha
- Linda Zhang (ORCID: https://orcid.org/0000-0003-2122-9771)
- Ana Carril Salaberry
Institutions
- Universitat Autònoma de Barcelona (ES)
- Nvidia (United Kingdom) (GB)
- Wellcome Centre for Human Neuroimaging (GB)
- Hospital de Sant Pau (ES)
- Hospital Universitario de La Princesa (ES)
- NIHR Queen Square Dementia Biomedical Research Unit (GB)
- National Hospital for Neurology and Neurosurgery (GB)
- Fundacion Centro De Investigacion De Enfermedades Neurologicas (ES)
- University College London (GB)
- Universidad Autónoma de Madrid (ES)
- Universidad Politécnica de Madrid (ES)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1002/alz.70296
- Citations
- 2
- Primary Topic
- Down syndrome and intellectual disability research
- Type
- article
- Field-Weighted Citation Impact
- 3.76
Funders
- Alzheimer's Association
- Fondation Jérôme Lejeune