U1‐70K and U1A and tau pathogenesis in demented and non‐demented individuals with Down syndrome
U1 mislocalization and tangle-like profiles appeared in frontal cortex layer III and V-VI neurons in Down syndrome (DS). Frontal cortex hnRNPA2B1 nuclear morphometric values decreased in layer III in DS with dementia. Frontal cortex SRSF2 and CLK1 nuclear proteins were unchanged in DSD+ and without dementia (DSD-).
Authors
- Muhammad Nadeem (ORCID: https://orcid.org/0000-0002-7066-4334)
- Chadwick M. Hales (ORCID: https://orcid.org/0000-0002-8757-7325)
- Michael Malek‐Ahmadi (ORCID: https://orcid.org/0000-0001-9901-3650)
- Jennifer C. Miguel (ORCID: https://orcid.org/0000-0001-5745-2241)
- Elizabeth Head
- Sylvia E. Perez (ORCID: https://orcid.org/0009-0009-1412-5721)
- Elliott J. Mufson
Institutions
- Alzheimer's Association (US)
- Barrow Neurological Institute (US)
- Emory University (US)
- University of California, Irvine (US)
- Institute for Neurodegenerative Disorders (US)
- Banner Alzheimer’s Institute
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1002/alz.70474
- Citations
- 1
- Primary Topic
- Down syndrome and intellectual disability research
- Type
- article
- Field-Weighted Citation Impact
- 1.88
Funders
- BrightFocus Foundation
- Barrow Neurological Foundation
- National Institutes of Health