Wnt5a suppresses colorectal cancer progression via TGF-β/NOTUM/OLFM4 axis in patient-derived organoids
Our study identifies a novel stromal-TME crosstalk mechanism wherein Wnt5a restrains CRC progression via TGF-β/NOTUM/OLFM4 signaling. The combinatorial efficacy of Wnt5a and 5-FU highlights a promising strategy to overcome chemoresistance. These findings emphasize the therapeutic potential of targeting stromal-derived pathways in CRC.
Authors
- Jia-Hui Huang (ORCID: https://orcid.org/0000-0002-9568-2563)
- Jiazi Yu (ORCID: https://orcid.org/0000-0002-8919-1178)
- Min Liu (ORCID: https://orcid.org/0000-0001-5183-1187)
- Yewei Huang (ORCID: https://orcid.org/0000-0002-8805-9351)
- Songlin Zhuang (ORCID: https://orcid.org/0000-0003-3072-0634)
Institutions
- Harbin Medical University (CN)
- Ningbo Medical Center Lihuili Hospital (CN)
- Fourth Affiliated Hospital of Harbin Medical University (CN)
- Zhejiang Pharmaceutical College (CN)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-08-05
- DOI
- https://doi.org/10.1186/s12964-025-02364-z
- Citations
- 1
- Primary Topic
- Wnt/β-catenin signaling in development and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Harbin Medical University
- Harbin Institute of Technology
- Natural Science Foundation of Heilongjiang Province