Role of SIRT6 in Chronic Periodontitis and Osteogenic Differentiation of Periodontal Ligament Stem Cells
SIRT6 is negatively correlated with clinical characteristics of CP. SIRT6 is downregulated in hPDLSCs under the inflammatory microenvironment, and overexpression of SIRT6 promotes osteogenic differentiation of hPDLSCs by suppressing EZH2 expression through deacetylation of H3K9ac.
Authors
- Hanna Gu
- Haixia Guo (ORCID: https://orcid.org/0009-0008-7187-6209)
- Rui Liu
- Jian Pan
- Hao Xu (ORCID: https://orcid.org/0000-0002-8311-506X)
Institutions
- Zhongshan Hospital (CN)
Publication Details
- Journal
- International Dental Journal
- Published
- 2025-08-05
- DOI
- https://doi.org/10.1016/j.identj.2025.100926
- Citations
- 1
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 1.47