Synthesis, crystal structure and Hirshfeld surface analysis of 3-ethyl-2-(methylsulfanyl)-5,5-diphenyl-3<i>H</i>-imidazol-4(5<i>H</i>)-one (Thiophenytoin analogue)
In the title mol-ecule, 3-ethyl-2-(methyl-sulfan-yl)-5,5-diphenyl-3<i>H</i>-imidazol-4(5<i>H</i>)-one, C<sub>18</sub>H<sub>18</sub>N<sub>2</sub>OS, the two substituent phenyl rings are inclined of 59.50 (7) and 83.53 (8)° with respect to the plane of the five-membered ring. The <i>S</i>-methyl group lies in this plane while the ethyl group is nearly perpendicular to it. In the crystal, weak C-H⋯O hydrogen bonds form inversion dimers, which pack <i>via</i> conventional van der Waals contacts. A Hirshfeld surface analysis was performed, showing the predominance of H⋯H and C⋯H/H⋯C contacts.
Authors
- Youssef Ramli (ORCID: https://orcid.org/0000-0002-6885-5692)
- Chiara Massera (ORCID: https://orcid.org/0000-0003-0230-1707)
- Walid Guerrab (ORCID: https://orcid.org/0000-0001-7317-4771)
- Abderrazzak El Moutaouakil Ala Allah (ORCID: https://orcid.org/0000-0002-4846-4547)
- Joel T. Mague (ORCID: https://orcid.org/0000-0003-3488-1945)
- Abdulsalam Alsubari
Institutions
- Tulane University (US)
- University of Parma (IT)
- Mohammed V University (MA)
- Yemenia University (YE)
Publication Details
- Journal
- Acta Crystallographica Section E Crystallographic Communications
- Published
- 2025-08-05
- DOI
- https://doi.org/10.1107/s205698902500698x
- Primary Topic
- Synthesis of heterocyclic compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Dipartimenti di Eccellenza
- Centre National pour la Recherche Scientifique et Technique