Scalable biocatalytic oxygenation of aliphatic amine derivatives using a class I unspecific peroxygenase
artUPO is revealed as an effective biocatalyst for the regioselective oxygenation of cycloalkylamines to form cyclic amino ketones on preparative scale. Furthermore, amino alcohols can be formed <i>via</i> the selective C-H oxygenation of isopropyl-tethered amine derivatives. Enantiomerically enriched amino alcohols are also accessible using a kinetic resolution approach.
Authors
- Jared Cartwright (ORCID: https://orcid.org/0000-0002-3723-4199)
- Gideon Grogan (ORCID: https://orcid.org/0000-0003-1383-7056)
- William P. Unsworth (ORCID: https://orcid.org/0000-0002-9169-5156)
- Jiacheng Li (ORCID: https://orcid.org/0000-0002-4404-4895)
- Katy A S Cornish
Institutions
- University of York (GB)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc03882k
- Citations
- 1
- Primary Topic
- Oxidative Organic Chemistry Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Engineering and Physical Sciences Research Council