Reduced Sphingosine-1-Phosphate Levels Exacerbate Type 2 Diabetes Mellitus and Associated Complications in a High-Fat Diet Mouse Model
Reduced S1P levels exacerbate T2DM symptoms, indicating that therapeutic targeting of S1P pathways may offer promising strategies for treating T2DM and its related complications.
Authors
- Hung‐Chieh Lo (ORCID: https://orcid.org/0000-0001-6079-8657)
- Ying-Kuo Liu (ORCID: https://orcid.org/0000-0002-6387-0324)
- Ching-Lu Chen
- Chin-Wang Hsu (ORCID: https://orcid.org/0000-0003-4973-1050)
- Shih‐Chang Hsu (ORCID: https://orcid.org/0000-0003-1010-1182)
- Shau-Ku Huang
- Chung-Te Liu
- Pei-Song Gao
Institutions
- Johns Hopkins University (US)
- National Health Research Institutes (TW)
- Johns Hopkins Medicine (US)
- Taipei Medical University Hospital (TW)
- Wan Fang Hospital (TW)
- Taipei Medical University (TW)
Publication Details
- Journal
- Endocrinology and Metabolism
- Published
- 2025-08-05
- DOI
- https://doi.org/10.3803/enm.2025.2360
- Primary Topic
- Sphingolipid Metabolism and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Taipei Medical University
- National Health Research Institutes
- National Science and Technology Council