KLK5 and KLK7 drive cervical carcinoma via KLK14-dependent RhoA and NF-κB pathways
This study underscores the critical roles of serine proteases KLK5, KLK7, and KLK14 in cervical carcinogenesis, suggesting that these serine proteases are promising targets for the development of novel therapeutic strategies in cervical cancer.
Authors
- Leandro M. Colli (ORCID: https://orcid.org/0000-0001-6928-1195)
- Elaine Zayas Marcelino da Silva (ORCID: https://orcid.org/0000-0002-2749-6275)
- João Paulo Bianchi Ximenez (ORCID: https://orcid.org/0000-0002-6414-5220)
- Thiago M. Cunha (ORCID: https://orcid.org/0000-0003-1084-0065)
- Ana Paula Lepique (ORCID: https://orcid.org/0000-0002-4707-2912)
- Gabriel Viliod Vieira (ORCID: https://orcid.org/0000-0002-6007-1498)
- Katiuchia Uzzun Sales (ORCID: https://orcid.org/0000-0002-3768-5790)
- Constantinos M. Mikelis (ORCID: https://orcid.org/0000-0002-6119-3307)
- Márcia Gaião Alves
- Raphael Sanches Peres (ORCID: https://orcid.org/0000-0002-0417-779X)
- Rodrigo Alberto Alves da Silva (ORCID: https://orcid.org/0000-0002-1032-0644)
- Silvana Maria Quintana (ORCID: https://orcid.org/0000-0002-9311-786X)
- Wilson A. Silva (ORCID: https://orcid.org/0000-0001-9364-2886)
- Μαργαρίτα Λάμπρου (ORCID: https://orcid.org/0000-0002-5986-0617)
- Carol Kobori da Fonseca (ORCID: https://orcid.org/0000-0002-3072-7142)
- Mateus Gonçalves Miranda (ORCID: https://orcid.org/0000-0002-5971-3844)
- Bruno Belmonte Martinelli Gomes (ORCID: https://orcid.org/0000-0002-6490-1970)
- Letícia Andrade Costa
- Laura Rodríguez (ORCID: https://orcid.org/0009-0000-9715-0475)
- Bruna Pinto Martins Brito (ORCID: https://orcid.org/0000-0002-8409-5742)
- Kevin Luiz Lopes-Delphino
- Camila Aparecida Coelho Brazão
- Vitor de Moura Arrais
Institutions
- University of Patras (GR)
- Universidade de São Paulo (BR)
Publication Details
- Journal
- Translational Oncology
- Published
- 2025-08-05
- DOI
- https://doi.org/10.1016/j.tranon.2025.102488
- Citations
- 1
- Primary Topic
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Type
- article
- Field-Weighted Citation Impact
- 1.63
Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Ministério da Educação
- Fundação de Apoio ao Ensino, Pesquisa e Assistência do Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo