Research on the Pathogenesis and Influencing Factors of Hypercalcemia in Graves’ Disease

格雷夫斯病(Graves’ disease, GD)作为常见的自身免疫性甲状腺疾病，常伴有多种并发症，高钙血症便是其中相对少见但不容忽视的一种。本综述旨在系统且深入地探讨GD合并高钙血症的影响因素，通过综合分析已有的研究成果，为临床诊断、治疗策略的制定以及预防措施的实施提供坚实的理论依据。相关研究表明，甲状腺激素水平的波动、自身免疫机制的异常、甲状旁腺功能的改变、维生素D代谢的失衡等多种因素相互交织，共同影响着这一并发症的发生与发展。Graves’ disease is a common autoimmune thyroid disease that often accompanies several complications, and hypercalcemia is one of the less common but not negligible ones. This review aims to systematically and thoroughly explore the influencing factors of hypercalcemia in Graves’ disease, by comprehensively analyzing the existing research findings, to provide a solid theoretical basis for clinical diagnosis, treatment strategy formulation, and prevention measures implementation. Related studies have shown that the fluctuation of thyroid hormone levels, abnormalities in the autoimmune mechanism, changes in the function of the parathyroid gland, and imbalances in vitamin D metabolism are intertwined and jointly affect the occurrence and development of this complication.