Cognitive and neuropsychological trajectories in patients with mixed neurodegenerative pathologies
Mixed neurodegenerative pathologies are common in the elderly population. The most common neurodegenerative pathologies were Alzheimer's disease neuropathologic change (ADNC), cerebrovascular disease (CVD), Lewy body dementia (LBD), and limbic-predominant age-related transactive response DNA-binding protein 43 encephalopathy (LATE). The addition of various combinations of comorbid CVD, LBD, and LATE to ADNC worsened overall performance on cognitive and neuropsychological testing across time. In general, the addition of multiple comorbid neurodegenerative pathologies did not influence the rate of decline across the evaluated time period.
Authors
- Justin Kauffman
- Mitzi M. Gonzales (ORCID: https://orcid.org/0000-0002-8467-0938)
- Tiago Gil Oliveira (ORCID: https://orcid.org/0000-0003-0509-0562)
- Susan K. Rohde (ORCID: https://orcid.org/0000-0002-9985-9645)
- Kevin Clare (ORCID: https://orcid.org/0000-0003-0300-6080)
- Elena V. Daoud (ORCID: https://orcid.org/0000-0001-8840-5106)
- Carolina Maldonado‐Díaz (ORCID: https://orcid.org/0000-0002-4185-7102)
- Charles L. White (ORCID: https://orcid.org/0000-0002-3870-2804)
- Kurt Farrell (ORCID: https://orcid.org/0000-0001-6955-7278)
- Connie Slocum
- Daniel Koenigsberg (ORCID: https://orcid.org/0009-0009-3861-8192)
- Timothy E. Richardson (ORCID: https://orcid.org/0000-0001-7068-5517)
- Satomi Hiya
- John F. Crary (ORCID: https://orcid.org/0000-0002-0556-293X)
- Gabriel A. Marx
- Jorge Samanamud (ORCID: https://orcid.org/0000-0003-2436-7539)
- Francisco Almeida (ORCID: https://orcid.org/0000-0002-8404-4136)
- Jamie M. Walker (ORCID: https://orcid.org/0000-0003-1263-7394)
- Victoria Flores‐Almazan
Institutions
- Cedars-Sinai Medical Center (US)
- Allen Institute for Brain Science (US)
- Amsterdam Neuroscience (NL)
- Hospital Braga (PT)
- Centro Hospitalar do Porto (PT)
- Vrije Universiteit Amsterdam (NL)
- The University of Texas Southwestern Medical Center (US)
- Icahn School of Medicine at Mount Sinai (US)
- University of Minho (PT)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1002/alz.70575
- Citations
- 3
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 4.41
Funders
- Texas Alzheimer's Research and Care Consortium
- National Institutes of Health
- National Institute on Aging