Exploration of the Therapeutic Time Window for Thrombectomy in Rat Models of Middle Cerebral Artery Ischemia‐Reperfusion
Taken together, our study indicates that MCAO 4 h is likely to be the therapeutic time window for thrombectomy in rat models of middle cerebral artery ischemia-reperfusion. Reperfusion injury beyond the time window leads to more severe disruption of the BBB, a significant increase in inflammatory products, and may ultimately result in a significant decline in neural function scores.
Authors
- Shumeng Li (ORCID: https://orcid.org/0009-0000-0240-1033)
- Xiao Ren (ORCID: https://orcid.org/0000-0002-6689-4700)
- Ying Xiong (ORCID: https://orcid.org/0000-0001-5943-1508)
- Daojun Hong (ORCID: https://orcid.org/0000-0003-1380-3534)
- Pengcheng Huang (ORCID: https://orcid.org/0000-0002-8532-5570)
- Yuan‐Jian Yang (ORCID: https://orcid.org/0000-0002-0175-5646)
- Jing Lin (ORCID: https://orcid.org/0009-0005-6239-1339)
- Yuting He (ORCID: https://orcid.org/0009-0005-3597-7828)
Institutions
- Nanchang University (CN)
- Jiangxi Mental Health Center (CN)
- First Affiliated Hospital of Nanchang University (CN)
Publication Details
- Journal
- Brain and Behavior
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1002/brb3.70713
- Primary Topic
- Acute Ischemic Stroke Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Jiangxi Province