A Synergistic Examination of Excitatory‐Inhibitory Balance in First‐Episode Schizophrenia Merging 7‐Tesla Magnetic Resonance Spectroscopic Imaging and Magnetoencephalography
Associations in FESz between GABA/Glu ratios, clinical ratings, and EAGBR power suggests this evoked gamma-band response reflects cortical hyperexcitability within the auditory system that is closely tied to disease debility at this early illness stage. These data highlight the potential of merging high-precision, in vivo neuro-chemical assays via 7-Tesla MRSI and physiological measures from MEG to validate established cellular models of disease.
Authors
- Dean F. Salisbury (ORCID: https://orcid.org/0000-0002-8533-0599)
- Mark T. Curtis (ORCID: https://orcid.org/0000-0003-0198-7583)
- Annie Blazer
- Brian A. Coffman (ORCID: https://orcid.org/0000-0001-9374-5105)
- Hoby H. Hetherington
- Fran López‐Caballero (ORCID: https://orcid.org/0000-0001-9194-2199)
- Alfredo L. Sklar (ORCID: https://orcid.org/0000-0003-4968-7643)
- Deepak K. Sarpal (ORCID: https://orcid.org/0000-0001-5842-6782)
- Chan‐Hong Moon
- Warren Snover
Institutions
- University of Pittsburgh (US)
- Washington University in St. Louis (US)
- ProterixBio (United States) (US)
- Resonance Research (United States) (US)
- University of Missouri (US)
Publication Details
- Journal
- Brain and Behavior
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1002/brb3.70735
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Brain and Behavior Research Foundation
- National Alliance for Research on Schizophrenia and Depression
- National Institute of Mental Health