Inflammatory Biomarkers Predictive of Psychopathology in Children With Physical Illness
Findings are not definitive evidence of a causal mechanism for physical-mental comorbidity in children but are consistent with reports in other populations. The predictive power of G-CSF, GM-CSF, and IL-6 supports the need for broader blood panels and routine mental health assessment, particularly for children on treatments that disrupt regulatory inflammatory pathways.
Authors
- Joe Quadrilatero (ORCID: https://orcid.org/0000-0002-9304-3557)
- Christy K. Y. Chan (ORCID: https://orcid.org/0000-0001-7585-3153)
- Mark A. Ferro (ORCID: https://orcid.org/0000-0002-0979-3233)
- Fasih A. Rahman (ORCID: https://orcid.org/0000-0003-4588-5378)
- Brian W. Timmons (ORCID: https://orcid.org/0000-0002-4063-9656)
Institutions
- University of Waterloo (CA)
- McMaster University (CA)
Publication Details
- Journal
- Brain and Behavior
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1002/brb3.70726
- Citations
- 1
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.58
Funders
- McMaster University
- Canada Research Chairs
- Canadian Institutes of Health Research