Decoding Proteus mirabilis biofilms: expression of selected virulence genes and association with antibiotic resistance
The virulence genes ureC, mrpA, speA, and rsbA are consistently found in P. mirabilis strains from both urine and non-urine specimens; however, their expression varies significantly, likely due to host or environmental factors. The presence of high multidrug-resistant (MDR) and extensively drug-resistant (XDR) P. mirabilis strains, potentially driven by the combination of these virulence genes, suggests an increase in virulence.
Authors
- Ayomi Dilhari (ORCID: https://orcid.org/0000-0002-8258-9976)
- Manjula Manoji Weerasekera (ORCID: https://orcid.org/0000-0002-8194-2205)
- Gayan Priyadarshana (ORCID: https://orcid.org/0000-0001-7130-3963)
- Imalka Munaweera (ORCID: https://orcid.org/0000-0002-0665-1563)
- Malshani Chathuranika Nissanka (ORCID: https://orcid.org/0000-0002-3636-9067)
- K.B.A.T. Bandara (ORCID: https://orcid.org/0000-0003-0455-2331)
- Jagath Anuradha Munasinghe
Institutions
- University of Sri Jayewardenepura (LK)
Publication Details
- Journal
- BMC Microbiology
- Published
- 2025-08-05
- DOI
- https://doi.org/10.1186/s12866-025-04212-z
- Citations
- 3
- Primary Topic
- Urinary Tract Infections Management
- Type
- article
- Field-Weighted Citation Impact
- 4.06
Funders
- University of Sri Jayewardenepura
- Fakultet Medicinskih Nauka, Univerziteta U Kragujevcu