Voluntary Activity Wheel Running Improves Hyperammonaemia‐Induced Skeletal Muscle Molecular and Metabolic Perturbations in Mice
VWR reverses hyperammonaemia-induced sarcopenia, protein synthesis/autophagy signalling perturbations, and mitochondrial oxidative dysfunction. Muscle mass, grip strength, signalling, and mitochondrial responses to VWR were not affected by hyperammonaemia. Increased expression of enzymes involved in the ammonia disposal pathway in skeletal muscle may be an adaptive response to hyperammonaemia. These data provide the rationale for exercise programmes in chronic diseases, including cirrhosis, even with hyperammonaemia.
Authors
- Srinivasan Dasarathy (ORCID: https://orcid.org/0000-0003-1774-0104)
- Takhar Kasumov (ORCID: https://orcid.org/0000-0003-2173-7231)
- Pugazhendhi Kannan (ORCID: https://orcid.org/0000-0003-2993-4838)
- Avinash Kumar (ORCID: https://orcid.org/0000-0001-5660-0337)
- Amy Attaway (ORCID: https://orcid.org/0000-0003-1959-9773)
- Thomas C. Jaramillo
- Roman V. Kondratov (ORCID: https://orcid.org/0000-0003-3449-745X)
- Khaviyaa Chandramohan
- Nicole Welch (ORCID: https://orcid.org/0000-0002-4655-5146)
- Saurabh Mishra (ORCID: https://orcid.org/0000-0001-8898-6609)
- A. A. Astaf’ev (ORCID: https://orcid.org/0000-0003-4872-2320)
- Annette Bellar
- Lopa Mishra (ORCID: https://orcid.org/0000-0002-6850-0808)
- Muaz Alsabbagh‐Alchirazi
Institutions
- Cleveland State University (US)
- Cleveland Clinic (US)
- Feinstein Institute for Medical Research (US)
- Cleveland Clinic Lerner College of Medicine (US)
- All India Institute of Medical Sciences (IN)
- Northeast Ohio Medical University (US)
Publication Details
- Journal
- Journal of Cachexia Sarcopenia and Muscle
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1002/jcsm.70031
- Citations
- 1
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 1.16