Lung Acetate Levels Decline in Correlation With Increased Type 2 Allergic Markers in a House Dust Mite Allergic Mouse Model
Overall, HDM-driven murine allergic airway inflammation induced changes in the faecal microbiome and reduced acetate in serum and lung tissue. Hereby, lung acetate levels correlated negatively with sensitisation and type-2 inflammation, but acetate itself did not suppress ex vivo HDM-induced cytokine release. Our findings provide new insights on the systemic effects of HDM-allergic inflammation along the gut-lung axis.
Authors
- Johan Garssen (ORCID: https://orcid.org/0000-0002-8678-9182)
- Rolf W. Sparidans (ORCID: https://orcid.org/0000-0002-3586-7937)
- Rudi W. Hendriks (ORCID: https://orcid.org/0000-0003-2291-0382)
- Gert Folkerts (ORCID: https://orcid.org/0000-0003-0630-2192)
- Roos E. M. Verstegen (ORCID: https://orcid.org/0009-0009-7830-3603)
- Atanaska I. Kostadinova
- Linette E. M. Willemsen (ORCID: https://orcid.org/0000-0001-9882-5331)
Institutions
- Utrecht University (NL)
- Erasmus MC (NL)
- Danone (Netherlands) (NL)
- Pharmo Institute (NL)
Publication Details
- Journal
- Clinical and Translational Allergy
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1002/clt2.70082
- Citations
- 4
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 4.66
Funders
- Health~Holland
- Lung Foundation Netherlands