Decreased IL-33 in the brain following repetitive mild traumatic brain injury contributes to cognitive impairment by inhibiting microglial phagocytosis
Dysfunction of the IL-33/ST2 axis following rmTBI leads to cognitive dysfunction via impairing microglial phagocytosis capacity and promoting neuronal damage. IL-33 would be a promising therapeutic target for alleviating neurodegeneration following rmTBI.
Authors
- Fanglian Chen (ORCID: https://orcid.org/0000-0002-9405-6974)
- Pan Liao (ORCID: https://orcid.org/0000-0002-6880-2048)
- Wei Cheng (ORCID: https://orcid.org/0000-0001-8009-7372)
- Bo Yan (ORCID: https://orcid.org/0000-0001-5038-9008)
- Zi-Han Zhang
- Jie Zhou (ORCID: https://orcid.org/0000-0002-0024-9485)
- Xintong Ge (ORCID: https://orcid.org/0000-0001-7153-952X)
- Mengtian Guo (ORCID: https://orcid.org/0000-0002-2556-4860)
- Ping Lei (ORCID: https://orcid.org/0000-0002-8410-7715)
- Meimei Li (ORCID: https://orcid.org/0000-0003-2035-0406)
- Yaru Liu (ORCID: https://orcid.org/0000-0002-8530-2547)
- Ze-Xi Jia
- Wei Zhang (ORCID: https://orcid.org/0000-0002-4280-1442)
- Fangyuan Cheng (ORCID: https://orcid.org/0009-0005-6567-7746)
Institutions
- Nankai University (CN)
- Beijing Chao-Yang Hospital, Capital Medical University (CN)
- Tianjin Medical University General Hospital (CN)
- Karolinska Institutet (SE)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Military Medical Research
- Published
- 2025-08-05
- DOI
- https://doi.org/10.1186/s40779-025-00631-1
- Citations
- 2
- Primary Topic
- IL-33, ST2, and ILC Pathways
- Type
- article
- Field-Weighted Citation Impact
- 1.59
Funders
- National Natural Science Foundation of China