PAK1 Signaling in Cancer: Multifaceted Roles and Therapeutic Implications

PAK1, a serine-threonine kinase, acts as an effector of Rac, Ras, and CDC42, which are pivotal in oncogenic signaling pathways. Its involvement spans critical cellular processes like cell cycle regulation, angiogenesis, and metastasis. PAK1 also influences therapeutic resistance mechanisms in various cancers. Serving as a linchpin in diverse signaling pathways pivotal to cancer progression, PAK1 positions itself as a promising therapeutic target. The comprehensive understanding of PAK1's roles in cancer biology underscores its potential for targeted interventions and offers prospects for improved cancer diagnostics and treatment strategies.