Exploring the IL-21/IL-21R Signaling Pathway in Rheumatoid Arthritis: Implications for Synoviocyte Survival and Disease Progression
This study elucidates, for the first time, the mechanism by which IL-21/IL-21R synergistically modulates the survival of RA-FLS through the "autophagy-ERS balance" and the USP18/GSDMD axis.
Authors
- Xiaoyan Cai (ORCID: https://orcid.org/0009-0008-3186-7113)
- Qiuhua Chen (ORCID: https://orcid.org/0000-0002-5481-6633)
- Liang Liang (ORCID: https://orcid.org/0000-0001-9941-8682)
- Tong Xie (ORCID: https://orcid.org/0000-0003-0791-8853)
- Xiaomei Huang
- Jie Lu
- Sijie Wang (ORCID: https://orcid.org/0000-0002-8525-1532)
- S.J Lin (ORCID: https://orcid.org/0000-0003-0470-2184)
Institutions
- Jinan University (CN)
- Guangdong Medical College (CN)
- Jinan University (LB)
- Affiliated Hospital of Guangdong Medical College Hospital (CN)
- First Affiliated Hospital of Jinan University (CN)
- South China University of Technology (CN)
Publication Details
- Journal
- Immunological Investigations
- Published
- 2025-08-04
- DOI
- https://doi.org/10.1080/08820139.2025.2542200
- Citations
- 3
- Primary Topic
- Rheumatoid Arthritis Research and Therapies
- Type
- article
- Field-Weighted Citation Impact
- 5.00